Abstract

Synthesis of Carbethoxycinnoline Derivatives and Antimicrobial Evaluation

3-Carbethoxy-6-substituted-4-methylcinnolines have been synthesized by cyclization of phenylhydrazonocarbethoxyacetones under microwave irradiations using polyphosphoric acid as condensing agent. The phenylhydrazonocarbethoxyacetones are prepared from benzenediazonium chloride and ethylacetoacetate. The antibacterial potential of the title compounds has been described against different bacteria’s.

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