Abstract

Synthesis of Acridine and its Derivative With Reference To Their Anti-Bacterial Efficacy

Author(s): Pravin A. Sonune, S. B. Rathod and Bushra Khanam

A new efficient procedure for the synthesis of 9(2-chlorophenyl aridine) under microwave irradiation and derivatives were characterized by different spectral technique IR and NMR spectroscopy. Reactions proceedwith very good to excellent yield at room temperature. Further were screened for their in vitro antibacterial activi-ties against pathogenic bacteria such as Salmonella typhi, Proteus vulgari, Klebsiella pnemoniae, E.schrichia, Shigella flexneri (gram –ve) and Staphylococcus aurea (gram +ve) bacteria by using agar-agar well diffusion meth-od. The results were evaluated after 24 hour of incubation. Chloro-substituted compounds showed antibactrial ac-tivity values in the low microbial range.

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