Abstract

Synthesis, Characterization and Antimicrobial Evaluation of Ru(II) and Co(III) Complexes of Phenylene-1,2-bis(iminoflavone) Derivatives

Author(s): Ashok Kumar Singh1*, Suresh Kumar Patel2andAsif Jafri3

Bioactive ruthenium and cobalt scaffolds of molecular formula [Ru(PPh3)2L1-4] and [Co(H2O)Cl L1-4] {where L1-4 represents the tetradentate ligands (E)-4-((2-((E)-(3-hydroxy-2-(4-substitutedphenyl)-4a,8a-dihydro-4H-chromen-4-ylidene)amino)phenyl)imino)-2-(4-substituted phenyl)-4H-chromen-3-ol (phenylenebis(iminoflavone)}have been synthesized from Ru(II) precursor [Ru(PPh3)4Cl2] and CoCl2.3H2O and phenylenebis(iminoflavone). Te-tradentate ligands of flavone (phenylenebis(iminoflavone)) have been derived by the condensation of 3-hydroxy-2-(4-substitutedphenyl)-4H-chromen-4-one with o-phenylenediamine. These ligands andscaffolds were characterized by elemental analysis, NMR, IR, ESI-MS, UV-Visible spectrometry, and conductometric measurement. These li-gands and scaffolds were screened the in vitro toxicity for antimicrobial activity against the growth of bacterial species Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhiand fungal species Candida albi-cansand Aspergillus flavus

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